Clinical Trials

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Overview

When you or a loved one is diagnosed with a serious disease, you want the specialist and treatment that can offer the very best possible outcome. That’s why we seek sponsorship to run clinical trials that test promising new treatments.

The ability to take part in clinical trials is exciting news for our patients, because participants receive access to leading-edge research treatments before they are generally available. Another bonus: procedures, drugs, and doctor visits associated with our clinical trials are generally provided at no cost to the patient.

Research Study Now Recruiting Patients with Mild to Moderate Alzheimer’s Disease (AD)

Jerold Mikszewski, MD, in the Neuromuscular Department, is the Principal Investigator of one of our latest clinical studies.

This study involves a treatment for mild to moderate Alzheimer’s Disease (AD). The objectives of this voluntary study are to compare treatment against placebo, evaluating 1) patient safety & 2) patient performance on neuropsychological & cognitive tests. Also brain volume & physiology are examined by MRI. Genotyping is done at screening to determine if patients are a non-carrier of a lipoprotein known as ApoE4. Only non-carriers are enrolled in the study (approx. 40% of AD population.). The study medicine is administered via IV infusion every 13 weeks for a total of 6 infusions. Participants are in the study up to 78 weeks.

Screening & enrollment are now open to both men and women. The following criteria must be met before you can be eligible for the study:

• 50 to 88 years of age
• Diagnosed with mild to moderate AD
• Patient must have caregiver who agrees to participate in study
• No neurological disease other than AD
• Mini-mental exam score of 16-26
• If on AD treatment, must be on stable dose regimen for at least 120 days prior to screening
• Must be non-carrier of ApoE4 allele – determined with blood test at screening

If you would like more information, please contact the Study Coordinator Elizabeth Vogt at 206-621-4391.

Research Study Now Recruiting Patients with Failed Back Surgery

Marshall Bedder, MD, in the Interventional Pain Management Dept., is the Principal Investigator of our latest device trial.

The study involves treatment options for failed back surgery syndrome. The objective of this voluntary study is to compare therapeutic effectiveness of a spinal cord stimulatory device with reoperation. Patients are randomized 1:1 to these treatments. Study duration is 3 years, but at 6 months subjects may crossover to other treatment if they wish to do so.

Screening & enrollment are now open to both men and women. The following criteria must be met before you can screen for the study:

• At least 18 years of age
• Individuals who have had at least one back surgery & who have leg pain, with or without lower back pain
• Leg pain duration for at least 6 months
• Patients must meet criteria for having another surgical intervention
• Must be willing to be randomized to either back surgery or the device

If you would like more information, please contact the Study Coordinator Elizabeth Vogt at 206-621-4391.